Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
Recent studies have suggested that long genes (>100 kb) are more likely to be misregulated in some neurological diseases, such as autism and Rett syndrome. Here the authors find that the apparent length-dependent trends previously observed in MeCP2 microarray and RNA-sequencing datasets disappear...
Guardado en:
Autores principales: | Ayush T. Raman, Amy E. Pohodich, Ying-Wooi Wan, Hari Krishna Yalamanchili, William E. Lowry, Huda Y. Zoghbi, Zhandong Liu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/558d10a20c1240ebb849e9756a465fe5 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
por: Derek J. C. Tai, et al.
Publicado: (2016) -
Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
por: Justin J. -L. Wong, et al.
Publicado: (2017) -
Sequence features accurately predict genome-wide MeCP2 binding in vivo
por: H. Tomas Rube, et al.
Publicado: (2016) -
MeCP2 regulates gene expression through recognition of H3K27me3
por: Wooje Lee, et al.
Publicado: (2020) -
MeCP2 deficiency exacerbates the neuroinflammatory setting and autoreactive response during an autoimmune challenge
por: M. I. Zalosnik, et al.
Publicado: (2021)