Quantitative imaging of transcription in living Drosophila embryos reveals the impact of core promoter motifs on promoter state dynamics

Here the authors decode how core promoter elements regulate rate limiting steps of transcription using quantitative live imaging, genetics and modeling in early Drosophila embryos. TATA-driven promoters require one rate-limiting step while INR promoters need an extra step associated with Pol II paus...

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Bibliographic Details
Main Authors: Virginia L. Pimmett, Matthieu Dejean, Carola Fernandez, Antonio Trullo, Edouard Bertrand, Ovidiu Radulescu, Mounia Lagha
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/55b0451fd1cf4e94bb3a8c2e059b2a51
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