Endothelial Jak3 expression enhances pro-hematopoietic angiocrine function in mice

Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show that Jak3 expressed in the bone marrow niche is im...

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Bibliographic Details
Main Authors: José Gabriel Barcia Durán, Tyler Lu, Sean Houghton, Fuqiang Geng, Ryan Schreiner, Jenny Xiang, Shahin Rafii, David Redmond, Raphaël Lis
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/55bfd49a01c64b54879f2fc1d1c36b2b
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