Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

The role of guanylate-binding proteins (GBPs) in innate immunity is increasingly recognized. Here the authors show that GBP4 activates inflammasome in zebrafish neutrophils, and that this process is critical for the clearance of Salmonellainfection via prostaglandin D2.

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Auteurs principaux:	Sylwia D. Tyrkalska, Sergio Candel, Diego Angosto, Victoria Gómez-Abellán, Fátima Martín-Sánchez, Diana García-Moreno, Rubén Zapata-Pérez, Álvaro Sánchez-Ferrer, María P. Sepulcre, Pablo Pelegrín, Victoriano Mulero
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/55bfda7fda31404dab8fdb2f0bb50c7f
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spelling	oai:doaj.org-article:55bfda7fda31404dab8fdb2f0bb50c7f2021-12-02T14:39:55ZNeutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins10.1038/ncomms120772041-1723https://doaj.org/article/55bfda7fda31404dab8fdb2f0bb50c7f2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12077https://doaj.org/toc/2041-1723The role of guanylate-binding proteins (GBPs) in innate immunity is increasingly recognized. Here the authors show that GBP4 activates inflammasome in zebrafish neutrophils, and that this process is critical for the clearance of Salmonellainfection via prostaglandin D2.Sylwia D. TyrkalskaSergio CandelDiego AngostoVictoria Gómez-AbellánFátima Martín-SánchezDiana García-MorenoRubén Zapata-PérezÁlvaro Sánchez-FerrerMaría P. SepulcrePablo PelegrínVictoriano MuleroNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sylwia D. Tyrkalska Sergio Candel Diego Angosto Victoria Gómez-Abellán Fátima Martín-Sánchez Diana García-Moreno Rubén Zapata-Pérez Álvaro Sánchez-Ferrer María P. Sepulcre Pablo Pelegrín Victoriano Mulero Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
description	The role of guanylate-binding proteins (GBPs) in innate immunity is increasingly recognized. Here the authors show that GBP4 activates inflammasome in zebrafish neutrophils, and that this process is critical for the clearance of Salmonellainfection via prostaglandin D2.
format	article
author	Sylwia D. Tyrkalska Sergio Candel Diego Angosto Victoria Gómez-Abellán Fátima Martín-Sánchez Diana García-Moreno Rubén Zapata-Pérez Álvaro Sánchez-Ferrer María P. Sepulcre Pablo Pelegrín Victoriano Mulero
author_facet	Sylwia D. Tyrkalska Sergio Candel Diego Angosto Victoria Gómez-Abellán Fátima Martín-Sánchez Diana García-Moreno Rubén Zapata-Pérez Álvaro Sánchez-Ferrer María P. Sepulcre Pablo Pelegrín Victoriano Mulero
author_sort	Sylwia D. Tyrkalska
title	Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
title_short	Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
title_full	Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
title_fullStr	Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
title_full_unstemmed	Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins
title_sort	neutrophils mediate salmonella typhimurium clearance through the gbp4 inflammasome-dependent production of prostaglandins
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/55bfda7fda31404dab8fdb2f0bb50c7f
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Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

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