ROLE OF TNFα/TNF-R1-SIGNALING PATHWAY IN CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST GLIOBLASTOMA CELL LINES

ROLE OF TNFα/TNF-R1-SIGNALING PATHWAY IN CYTOTOXIC ACTIVITY OF DENDRITIC CELLS AGAINST GLIOBLASTOMA CELL LINES

Dendritic cells (DCs) of patients with high-grade brain glioma exhibit impaired expression of membrane TNFα associated with low DC cytotoxicity against TNF-R1-expressing tumor cell line HEp-2. To assess the significance of these findings, we investigated a role of TNFα/TNF-R1-signaling pathway in DC...

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Main Authors: T. V. Tyrinova, S. V. Mishinov, O. Yu. Leplina, A. A. Alshevskaya, Yu. D. Kurochkina, E. A. Oleynik, А. V. Kalinovskiy, Yu. A. Lopatnikova, S. V. Chernov, V. V. Stupak, S. V. Sennikov, A. A. Ostanin, E. R. Chernykh
Format: article
Language:RU
Published: SPb RAACI 2018
Subjects:
dendritic cells
interferon-alpha
tumor necrosis factor alpha
tnf-r1
glioblastoma multiforme
Immunologic diseases. Allergy
RC581-607
Online Access:https://doaj.org/article/55d82abeb5a845fca8999827edb477a9
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https://doaj.org/article/55d82abeb5a845fca8999827edb477a9

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