Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects.

Eukaryotic initiation factor (eIF)4E is over-expressed in many types of cancer such as breast, head and neck, and lung. A consequence of increased levels of eIF4E is the preferential translation of pro-tumorigenic proteins (e.g. c-Myc and vascular endothelial growth factor) and as a result is regard...

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Auteurs principaux: Weizhuang Zhou, Soo T Quah, Chandra S Verma, Yun Liu, David P Lane, Christopher J Brown
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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R
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Accès en ligne:https://doaj.org/article/55da2c89814e4f45acde4561acea2d16
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