CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves

NAD+ and cognitive hypersensitivity during aging Cognitive dysfunction is one of the most concerning outcomes in global population aging. However, the mechanisms of cognitive impairment during aging remain elusive. We found that in old mice, levels of nicotinamide adenine dinucleotide (NAD+), an ess...

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Autores principales:	Sean Johnson, David F. Wozniak, S. Imai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5620c8e0b04c4040b4846d81718e1b72
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spelling	oai:doaj.org-article:5620c8e0b04c4040b4846d81718e1b722021-12-02T14:18:31ZCA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves10.1038/s41514-018-0029-z2056-3973https://doaj.org/article/5620c8e0b04c4040b4846d81718e1b722018-11-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0029-zhttps://doaj.org/toc/2056-3973NAD+ and cognitive hypersensitivity during aging Cognitive dysfunction is one of the most concerning outcomes in global population aging. However, the mechanisms of cognitive impairment during aging remain elusive. We found that in old mice, levels of nicotinamide adenine dinucleotide (NAD+), an essential chemical for all living organisms, declined in the hippocampus, a critical part of the brain for memory and learning. We also found that age-associated hypersensitivity in cognitive and behavioral functions (cognitive hypersensitivity) was induced by reduced NAD+ availability in the hippocampus. Supplementation of nicotinamide mononucleotide (NMN), a critical chemical that is converted to NAD+, is able to mitigate the cognitive hypersensitivity observed in old mice. Our findings provide new insights into how NAD+ decline affects age-associated anxiety/depression and how such impairments can be prevented or treated by enhancing NAD+.Sean JohnsonDavid F. WozniakS. ImaiNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Sean Johnson David F. Wozniak S. Imai CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
description	NAD+ and cognitive hypersensitivity during aging Cognitive dysfunction is one of the most concerning outcomes in global population aging. However, the mechanisms of cognitive impairment during aging remain elusive. We found that in old mice, levels of nicotinamide adenine dinucleotide (NAD+), an essential chemical for all living organisms, declined in the hippocampus, a critical part of the brain for memory and learning. We also found that age-associated hypersensitivity in cognitive and behavioral functions (cognitive hypersensitivity) was induced by reduced NAD+ availability in the hippocampus. Supplementation of nicotinamide mononucleotide (NMN), a critical chemical that is converted to NAD+, is able to mitigate the cognitive hypersensitivity observed in old mice. Our findings provide new insights into how NAD+ decline affects age-associated anxiety/depression and how such impairments can be prevented or treated by enhancing NAD+.
format	article
author	Sean Johnson David F. Wozniak S. Imai
author_facet	Sean Johnson David F. Wozniak S. Imai
author_sort	Sean Johnson
title	CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
title_short	CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
title_full	CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
title_fullStr	CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
title_full_unstemmed	CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
title_sort	ca1 nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5620c8e0b04c4040b4846d81718e1b72
work_keys_str_mv	AT seanjohnson ca1namptknockdownrecapitulateshippocampalcognitivephenotypesinoldmicewhichnicotinamidemononucleotideimproves AT davidfwozniak ca1namptknockdownrecapitulateshippocampalcognitivephenotypesinoldmicewhichnicotinamidemononucleotideimproves AT simai ca1namptknockdownrecapitulateshippocampalcognitivephenotypesinoldmicewhichnicotinamidemononucleotideimproves
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CA1 Nampt knockdown recapitulates hippocampal cognitive phenotypes in old mice which nicotinamide mononucleotide improves

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