Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects

A SNP distant from the human insulin (INS) gene near the KRTAP5-6 gene confers increased susceptibility to type 2 diabetes when present on the paternal allele while decreased susceptibility when on the maternal allele. Here the authors show that long-range contacts between the INS locus and the KRTA...

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Autores principales: Xing Jian, Gary Felsenfeld
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/56388fac1a3b48b0b366720ad06fb8ac
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