Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects

A SNP distant from the human insulin (INS) gene near the KRTAP5-6 gene confers increased susceptibility to type 2 diabetes when present on the paternal allele while decreased susceptibility when on the maternal allele. Here the authors show that long-range contacts between the INS locus and the KRTA...

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Autores principales:	Xing Jian, Gary Felsenfeld
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56388fac1a3b48b0b366720ad06fb8ac
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spelling	oai:doaj.org-article:56388fac1a3b48b0b366720ad06fb8ac2021-12-02T17:01:29ZLarge parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects10.1038/s41467-021-24635-22041-1723https://doaj.org/article/56388fac1a3b48b0b366720ad06fb8ac2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24635-2https://doaj.org/toc/2041-1723A SNP distant from the human insulin (INS) gene near the KRTAP5-6 gene confers increased susceptibility to type 2 diabetes when present on the paternal allele while decreased susceptibility when on the maternal allele. Here the authors show that long-range contacts between the INS locus and the KRTAP5-6 gene locus distinguish paternal and maternal alleles.Xing JianGary FelsenfeldNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xing Jian Gary Felsenfeld Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
description	A SNP distant from the human insulin (INS) gene near the KRTAP5-6 gene confers increased susceptibility to type 2 diabetes when present on the paternal allele while decreased susceptibility when on the maternal allele. Here the authors show that long-range contacts between the INS locus and the KRTAP5-6 gene locus distinguish paternal and maternal alleles.
format	article
author	Xing Jian Gary Felsenfeld
author_facet	Xing Jian Gary Felsenfeld
author_sort	Xing Jian
title	Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
title_short	Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
title_full	Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
title_fullStr	Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
title_full_unstemmed	Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
title_sort	large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56388fac1a3b48b0b366720ad06fb8ac
work_keys_str_mv	AT xingjian largeparentaldifferencesinchromatinorganizationinpancreaticbetacelllineexplainingdiabetessusceptibilityeffects AT garyfelsenfeld largeparentaldifferencesinchromatinorganizationinpancreaticbetacelllineexplainingdiabetessusceptibilityeffects
_version_	1718382083865313280

Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects

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