Mechanism of membrane-curvature generation by ER-tubule shaping proteins

The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments...

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Autores principales: Ning Wang, Lindsay D. Clark, Yuan Gao, Michael M. Kozlov, Tom Shemesh, Tom A. Rapoport
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/56438c7966b446978619a8f0309f5673
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