Mechanism of membrane-curvature generation by ER-tubule shaping proteins

The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments...

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Autores principales:	Ning Wang, Lindsay D. Clark, Yuan Gao, Michael M. Kozlov, Tom Shemesh, Tom A. Rapoport
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56438c7966b446978619a8f0309f5673
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spelling	oai:doaj.org-article:56438c7966b446978619a8f0309f56732021-12-02T14:16:13ZMechanism of membrane-curvature generation by ER-tubule shaping proteins10.1038/s41467-020-20625-y2041-1723https://doaj.org/article/56438c7966b446978619a8f0309f56732021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20625-yhttps://doaj.org/toc/2041-1723The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments to introduce high membrane curvature that can even lead to the formation of lipoprotein particles.Ning WangLindsay D. ClarkYuan GaoMichael M. KozlovTom ShemeshTom A. RapoportNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ning Wang Lindsay D. Clark Yuan Gao Michael M. Kozlov Tom Shemesh Tom A. Rapoport Mechanism of membrane-curvature generation by ER-tubule shaping proteins
description	The endoplasmic reticulum network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs, but how they introduce curvature is poorly understood. Here authors show that REEPs form homodimers and use their amphipathic helix and trans-membrane segments to introduce high membrane curvature that can even lead to the formation of lipoprotein particles.
format	article
author	Ning Wang Lindsay D. Clark Yuan Gao Michael M. Kozlov Tom Shemesh Tom A. Rapoport
author_facet	Ning Wang Lindsay D. Clark Yuan Gao Michael M. Kozlov Tom Shemesh Tom A. Rapoport
author_sort	Ning Wang
title	Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_short	Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_full	Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_fullStr	Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_full_unstemmed	Mechanism of membrane-curvature generation by ER-tubule shaping proteins
title_sort	mechanism of membrane-curvature generation by er-tubule shaping proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56438c7966b446978619a8f0309f5673
work_keys_str_mv	AT ningwang mechanismofmembranecurvaturegenerationbyertubuleshapingproteins AT lindsaydclark mechanismofmembranecurvaturegenerationbyertubuleshapingproteins AT yuangao mechanismofmembranecurvaturegenerationbyertubuleshapingproteins AT michaelmkozlov mechanismofmembranecurvaturegenerationbyertubuleshapingproteins AT tomshemesh mechanismofmembranecurvaturegenerationbyertubuleshapingproteins AT tomarapoport mechanismofmembranecurvaturegenerationbyertubuleshapingproteins
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Mechanism of membrane-curvature generation by ER-tubule shaping proteins

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