A Study on Synthesis and Upscaling of 2′-<i>O</i>-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis

A Study on Synthesis and Upscaling of 2′-<i>O</i>-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis

2′-<i>O</i>-(<i>N</i>-(Aminoethyl)carbamoyl)methyl-modified 5-methyluridine (AECM-MeU) and 5-methylcytidine (AECM-MeC) phosphoramidites are reported for the first time and prepared in multigram quantities. The syntheses of AECM-MeU and AECM-MeC nucleosides are designed for la...

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Autores principales: Kristina Karalė, Martin Bollmark, Rouven Stulz, Dmytro Honcharenko, Ulf Tedebark, Roger Strömberg
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
2′-<i>O</i>-(N-(aminoethyl)carbamoyl)methyl modification
phase transfer catalysis (PTC)
5-methyluridine
5-methylcytidine
oligonucleotides
alkylation
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/567574a25e0b4173a9ab63f4adf01037
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https://doaj.org/article/567574a25e0b4173a9ab63f4adf01037

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