A Study on Synthesis and Upscaling of 2′-O-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis

2′-O-(N-(Aminoethyl)carbamoyl)methyl-modified 5-methyluridine (AECM-MeU) and 5-methylcytidine (AECM-MeC) phosphoramidites are reported for the first time and prepared in multigram quantities. The syntheses of AECM-MeU and AECM-MeC nucleosides are designed for la...

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Autores principales:	Kristina Karalė, Martin Bollmark, Rouven Stulz, Dmytro Honcharenko, Ulf Tedebark, Roger Strömberg
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	2′-<i>O</i>-(N-(aminoethyl)carbamoyl)methyl modification phase transfer catalysis (PTC) 5-methyluridine 5-methylcytidine oligonucleotides alkylation Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/567574a25e0b4173a9ab63f4adf01037
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A Study on Synthesis and Upscaling of 2′-<i>O</i>-AECM-5-methyl Pyrimidine Phosphoramidites for Oligonucleotide Synthesis

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