A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.

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Autores principales: Lin Wang, Jingzheng Li, Hu Zhou, Weidao Zhang, Jing Gao, Ping Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/56a478158e624d08ac79bc64bc5d9483
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