A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability

Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.

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Autores principales: Lin Wang, Jingzheng Li, Hu Zhou, Weidao Zhang, Jing Gao, Ping Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/56a478158e624d08ac79bc64bc5d9483
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spelling oai:doaj.org-article:56a478158e624d08ac79bc64bc5d94832021-12-02T18:48:25ZA novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability10.1038/s41467-021-25827-62041-1723https://doaj.org/article/56a478158e624d08ac79bc64bc5d94832021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25827-6https://doaj.org/toc/2041-1723Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.Lin WangJingzheng LiHu ZhouWeidao ZhangJing GaoPing ZhengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lin Wang
Jingzheng Li
Hu Zhou
Weidao Zhang
Jing Gao
Ping Zheng
A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
description Various lncRNAs functions have been associated to replication stress and DNA double strand breaks in ESC. Here the authors reveal the lncRNA Discn-NCL-RPA axis pathway, which can regulate the availability of RPA pool for DNA replication stress response and repair.
format article
author Lin Wang
Jingzheng Li
Hu Zhou
Weidao Zhang
Jing Gao
Ping Zheng
author_facet Lin Wang
Jingzheng Li
Hu Zhou
Weidao Zhang
Jing Gao
Ping Zheng
author_sort Lin Wang
title A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_short A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_full A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_fullStr A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_full_unstemmed A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability
title_sort novel lncrna discn fine-tunes replication protein a (rpa) availability to promote genomic stability
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/56a478158e624d08ac79bc64bc5d9483
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