Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers

Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers

Abstract The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopathological study of MRN in sporadic breast cancers. We have...

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Autores principales: Adel Alblihy, Ahmed Shoqafi, Michael S. Toss, Mashael Algethami, Anna E. Harris, Jennie N. Jeyapalan, Tarek Abdel-Fatah, Juliette Servante, Stephen Y. T. Chan, Andrew Green, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/56ed86e24ee6429fa04c2441b2232edb
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https://doaj.org/article/56ed86e24ee6429fa04c2441b2232edb

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