Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity Against Mycobacterium tuberculosis

Abstract Bacillus Calmette-Guerin (BCG) is the only vaccine against TB and has limited protection efficacy, which wanes past adolescence. Multifunctional CD8+ T cells (IFN-γ+/TNF-α+/IL-2+) are associated with lower reactivation risk and enhanced control of active Mtb infection. Since boosting with B...

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Autores principales: Charles B. Chesson, Matthew Huante, Rebecca J. Nusbaum, Aida G. Walker, Tara M. Clover, Jagannath Chinnaswamy, Janice J. Endsley, Jai S. Rudra
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5703a72574d74332afa1078b39195189
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