HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen dive...

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Autores principales:	Patricia T. Illing, Phillip Pymm, Nathan P. Croft, Hugo G. Hilton, Vladimir Jojic, Alex S. Han, Juan L. Mendoza, Nicole A. Mifsud, Nadine L. Dudek, James McCluskey, Peter Parham, Jamie Rossjohn, Julian P. Vivian, Anthony W. Purcell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57210117d3c3489fa9dd810651f36182
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spelling	oai:doaj.org-article:57210117d3c3489fa9dd810651f361822021-12-02T14:39:44ZHLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome10.1038/s41467-018-07109-w2041-1723https://doaj.org/article/57210117d3c3489fa9dd810651f361822018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07109-whttps://doaj.org/toc/2041-1723Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.Patricia T. IllingPhillip PymmNathan P. CroftHugo G. HiltonVladimir JojicAlex S. HanJuan L. MendozaNicole A. MifsudNadine L. DudekJames McCluskeyPeter ParhamJamie RossjohnJulian P. VivianAnthony W. PurcellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Patricia T. Illing Phillip Pymm Nathan P. Croft Hugo G. Hilton Vladimir Jojic Alex S. Han Juan L. Mendoza Nicole A. Mifsud Nadine L. Dudek James McCluskey Peter Parham Jamie Rossjohn Julian P. Vivian Anthony W. Purcell HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
description	Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.
format	article
author	Patricia T. Illing Phillip Pymm Nathan P. Croft Hugo G. Hilton Vladimir Jojic Alex S. Han Juan L. Mendoza Nicole A. Mifsud Nadine L. Dudek James McCluskey Peter Parham Jamie Rossjohn Julian P. Vivian Anthony W. Purcell
author_facet	Patricia T. Illing Phillip Pymm Nathan P. Croft Hugo G. Hilton Vladimir Jojic Alex S. Han Juan L. Mendoza Nicole A. Mifsud Nadine L. Dudek James McCluskey Peter Parham Jamie Rossjohn Julian P. Vivian Anthony W. Purcell
author_sort	Patricia T. Illing
title	HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
title_short	HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
title_full	HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
title_fullStr	HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
title_full_unstemmed	HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
title_sort	hla-b57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/57210117d3c3489fa9dd810651f36182
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HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

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