Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites.

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin...

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Autores principales: Brad E Sleebs, Sash Lopaticki, Danushka S Marapana, Matthew T O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja Günther, Lachlan W Whitehead, Kym N Lowes, Lea Barfod, Lars Hviid, Philip J Shaw, Anthony N Hodder, Brian J Smith, Alan F Cowman, Justin A Boddey
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/577c998d81b343c095e557df66f4d3e1
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