A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.

LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50 ≤ 0.5 µM), and was posited to exploit the physiological difference between static viral membranes and biogenic cellular membranes. We now report on the molecular...

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Autores principales: Frederic Vigant, Jihye Lee, Axel Hollmann, Lukas B Tanner, Zeynep Akyol Ataman, Tatyana Yun, Guanghou Shui, Hector C Aguilar, Dong Zhang, David Meriwether, Gleyder Roman-Sosa, Lindsey R Robinson, Terry L Juelich, Hubert Buczkowski, Sunwen Chou, Miguel A R B Castanho, Mike C Wolf, Jennifer K Smith, Ashley Banyard, Margaret Kielian, Srinivasa Reddy, Markus R Wenk, Matthias Selke, Nuno C Santos, Alexander N Freiberg, Michael E Jung, Benhur Lee
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/5782a66da0c04ff5a689050288b55985
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https://doaj.org/article/5782a66da0c04ff5a689050288b55985

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