Human embryo polarization requires PLC signaling to mediate trophectoderm specification

Apico-basal polarization of cells within the embryo is critical for the segregation of distinct lineages during mammalian development. Polarized cells become the trophectoderm (TE), which forms the placenta, and apolar cells become the inner cell mass (ICM), the founding population of the fetus. The...

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Autores principales:	Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	human embryo cell polarity preimplantation Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/579ed260e0bd4dd89e8d938ef11881a9
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Human embryo polarization requires PLC signaling to mediate trophectoderm specification

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