Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo

par Qi Chen, Junchao Shi, Yi Tao, Magdalena Zernicka-Goetz
Publié 2018

Autophagy-mediated apoptosis eliminates aneuploid cells in a mouse model of chromosome mosaicism

par Shruti Singla, Lisa K. Iwamoto-Stohl, Meng Zhu, Magdalena Zernicka-Goetz
Publié 2020

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

par Meng Zhu, Chuen Yan Leung, Marta N. Shahbazi, Magdalena Zernicka-Goetz
Publié 2017

Reconstructing aspects of human embryogenesis with pluripotent stem cells

par Berna Sozen, Victoria Jorgensen, Bailey A. T. Weatherbee, Sisi Chen, Meng Zhu, Magdalena Zernicka-Goetz
Publié 2021

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

par Neophytos Christodoulou, Antonia Weberling, Douglas Strathdee, Kurt I. Anderson, Paul Timpson, Magdalena Zernicka-Goetz
Publié 2019

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

par Helen Bolton, Sarah J. L. Graham, Niels Van der Aa, Parveen Kumar, Koen Theunis, Elia Fernandez Gallardo, Thierry Voet, Magdalena Zernicka-Goetz
Publié 2016

Developmental potential of aneuploid human embryos cultured beyond implantation

par Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz
Publié 2020

Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids

par Thomas M Rawlings, Komal Makwana, Deborah M Taylor, Matteo A Molè, Katherine J Fishwick, Maria Tryfonos, Joshua Odendaal, Amelia Hawkes, Magdalena Zernicka-Goetz, Geraldine M Hartshorne, Jan J Brosens, Emma S Lucas
Publié 2021

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

par Matteo A. Molè, Tim H. H. Coorens, Marta N. Shahbazi, Antonia Weberling, Bailey A. T. Weatherbee, Carlos W. Gantner, Carmen Sancho-Serra, Lucy Richardson, Abbie Drinkwater, Najma Syed, Stephanie Engley, Philip Snell, Leila Christie, Kay Elder, Alison Campbell, Simon Fishel, Sam Behjati, Roser Vento-Tormo, Magdalena Zernicka-Goetz
Publié 2021

Human embryo polarization requires PLC signaling to mediate trophectoderm specification

par Meng Zhu, Marta Shahbazi, Angel Martin, Chuanxin Zhang, Berna Sozen, Mate Borsos, Rachel S Mandelbaum, Richard J Paulson, Matteo A Mole, Marga Esbert, Shiny Titus, Richard T Scott, Alison Campbell, Simon Fishel, Viviana Gradinaru, Han Zhao, Keliang Wu, Zi-Jiang Chen, Emre Seli, Maria J de los Santos, Magdalena Zernicka Goetz
Publié 2021

RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

par Angelos Papaspyropoulos, Leanne Bradley, Asmita Thapa, Chuen Yan Leung, Konstantinos Toskas, Delia Koennig, Dafni-Eleftheria Pefani, Cinzia Raso, Claudia Grou, Garth Hamilton, Nikola Vlahov, Anna Grawenda, Syed Haider, Jagat Chauhan, Ludovico Buti, Alexander Kanapin, Xin Lu, Francesca Buffa, Grigory Dianov, Alex von Kriegsheim, David Matallanas, Anastasia Samsonova, Magdalena Zernicka-Goetz, Eric O’Neill
Publié 2018