Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition

Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to an eIF4E binding-incompatible state to control tr...

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Autores principales:	Jennifer E. Dawson, Alaji Bah, Zhenfu Zhang, Robert M. Vernon, Hong Lin, P. Andrew Chong, Manasvi Vanama, Nahum Sonenberg, Claudiu C. Gradinaru, Julie D. Forman-Kay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf
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spelling	oai:doaj.org-article:57e3644d3e9b45b39d26e1a240848dcf2021-12-02T16:04:25ZNon-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition10.1038/s41467-020-16783-82041-1723https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16783-8https://doaj.org/toc/2041-1723Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to an eIF4E binding-incompatible state to control translation.Jennifer E. DawsonAlaji BahZhenfu ZhangRobert M. VernonHong LinP. Andrew ChongManasvi VanamaNahum SonenbergClaudiu C. GradinaruJulie D. Forman-KayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer E. Dawson Alaji Bah Zhenfu Zhang Robert M. Vernon Hong Lin P. Andrew Chong Manasvi Vanama Nahum Sonenberg Claudiu C. Gradinaru Julie D. Forman-Kay Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
description	Phosphorylation of eIF4E binding proteins (4E-BPs) controls their folding and regulates cap-dependent translation. Here, the authors show that phosphorylation of the C-terminal disordered region stabilizes the non-cooperatively folded 4E-BP domain to an eIF4E binding-incompatible state to control translation.
format	article
author	Jennifer E. Dawson Alaji Bah Zhenfu Zhang Robert M. Vernon Hong Lin P. Andrew Chong Manasvi Vanama Nahum Sonenberg Claudiu C. Gradinaru Julie D. Forman-Kay
author_facet	Jennifer E. Dawson Alaji Bah Zhenfu Zhang Robert M. Vernon Hong Lin P. Andrew Chong Manasvi Vanama Nahum Sonenberg Claudiu C. Gradinaru Julie D. Forman-Kay
author_sort	Jennifer E. Dawson
title	Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
title_short	Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
title_full	Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
title_fullStr	Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
title_full_unstemmed	Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
title_sort	non-cooperative 4e-bp2 folding with exchange between eif4e-binding and binding-incompatible states tunes cap-dependent translation inhibition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/57e3644d3e9b45b39d26e1a240848dcf
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Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition

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