Translation of human Δ133p53 mRNA and its targeting by antisense oligonucleotides complementary to the 5'-terminal region of this mRNA.

The p53 protein is expressed as at least twelve protein isoforms. Within intron 4 of the human TP53 gene, a P2 transcription initiation site is located and this transcript encodes two p53 isoforms: Δ133p53 and Δ160p53. Here, the secondary structure of the 5'-terminal region of P2-initiated mRNA...

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Autores principales: Paulina Żydowicz-Machtel, Mariola Dutkiewicz, Agata Swiatkowska, Dorota Gurda-Woźna, Jerzy Ciesiołka
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/58104ef2ee3e40c29e2fdfe9a66fa15d
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