Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis

Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis

Abstract Skeletal muscle and the neuromuscular junction are the earliest sites to manifest pathological changes in amyotrophic lateral sclerosis (ALS). Based on prior studies, we have identified a molecular signature in muscle that develops early in ALS and parallels disease progression. This signat...

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Autores principales: Thaddaeus Kwan, Mohamed Kazamel, Kristina Thoenes, Ying Si, Nan Jiang, Peter H. King
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/5818ae8790184c18a4eb0a039ecf46e0
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