Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy

Current methods for haematopoietic stem cell gene therapy are laborious and require special licensed facilities. Here the authors develop a semi-automated protocol using a commercially available device to allow for benchtop generation of gene-modified blood cell products for transplantation, that me...

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Autores principales:	Jennifer E. Adair, Timothy Waters, Kevin G. Haworth, Sara P. Kubek, Grant D. Trobridge, Jonah D. Hocum, Shelly Heimfeld, Hans-Peter Kiem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/583cfd673dbc436f8e0a56f2549b1b65
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spelling	oai:doaj.org-article:583cfd673dbc436f8e0a56f2549b1b652021-12-02T17:32:20ZSemi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy10.1038/ncomms131732041-1723https://doaj.org/article/583cfd673dbc436f8e0a56f2549b1b652016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13173https://doaj.org/toc/2041-1723Current methods for haematopoietic stem cell gene therapy are laborious and require special licensed facilities. Here the authors develop a semi-automated protocol using a commercially available device to allow for benchtop generation of gene-modified blood cell products for transplantation, that meet current standards.Jennifer E. AdairTimothy WatersKevin G. HaworthSara P. KubekGrant D. TrobridgeJonah D. HocumShelly HeimfeldHans-Peter KiemNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jennifer E. Adair Timothy Waters Kevin G. Haworth Sara P. Kubek Grant D. Trobridge Jonah D. Hocum Shelly Heimfeld Hans-Peter Kiem Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
description	Current methods for haematopoietic stem cell gene therapy are laborious and require special licensed facilities. Here the authors develop a semi-automated protocol using a commercially available device to allow for benchtop generation of gene-modified blood cell products for transplantation, that meet current standards.
format	article
author	Jennifer E. Adair Timothy Waters Kevin G. Haworth Sara P. Kubek Grant D. Trobridge Jonah D. Hocum Shelly Heimfeld Hans-Peter Kiem
author_facet	Jennifer E. Adair Timothy Waters Kevin G. Haworth Sara P. Kubek Grant D. Trobridge Jonah D. Hocum Shelly Heimfeld Hans-Peter Kiem
author_sort	Jennifer E. Adair
title	Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
title_short	Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
title_full	Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
title_fullStr	Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
title_full_unstemmed	Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
title_sort	semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/583cfd673dbc436f8e0a56f2549b1b65
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Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy

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