Inhibition of ERK 1/2 kinases prevents tendon matrix breakdown

Abstract Tendon extracellular matrix (ECM) mechanical unloading results in tissue degradation and breakdown, with niche-dependent cellular stress directing proteolytic degradation of tendon. Here, we show that the extracellular-signal regulated kinase (ERK) pathway is central in tendon degradation o...

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Autores principales: Ulrich Blache, Stefania L. Wunderli, Amro A. Hussien, Tino Stauber, Gabriel Flückiger, Maja Bollhalder, Barbara Niederöst, Sandro F. Fucentese, Jess G. Snedeker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5855c215acdf4349bfb11315c1a27b02
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