Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular disse...

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Main Authors:	Shu-Chen Liu, Tien Hsu, Yu-Sun Chang, An-Ko Chung, Shih Sheng Jiang, Chun-Nan OuYang, Chiou-Hwa Yuh, Chuen Hsueh, Ya-Ping Liu, Ngan-Ming Tsang
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/5859dcee62b843f5bc95e474b541df8d
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spelling	oai:doaj.org-article:5859dcee62b843f5bc95e474b541df8d2021-12-02T14:40:55ZCytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling10.1038/s41467-018-07660-62041-1723https://doaj.org/article/5859dcee62b843f5bc95e474b541df8d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07660-6https://doaj.org/toc/2041-1723Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular dissemination via the YAP1-FAK/PXN axis.Shu-Chen LiuTien HsuYu-Sun ChangAn-Ko ChungShih Sheng JiangChun-Nan OuYangChiou-Hwa YuhChuen HsuehYa-Ping LiuNgan-Ming TsangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shu-Chen Liu Tien Hsu Yu-Sun Chang An-Ko Chung Shih Sheng Jiang Chun-Nan OuYang Chiou-Hwa Yuh Chuen Hsueh Ya-Ping Liu Ngan-Ming Tsang Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
description	Molecular pathways regulating nasopharyngeal carcinoma (NPC) metastasis are unclear. Here they report higher levels of cytoplasmic leukemia inhibitory factor (cLIF) and LIF receptor (LIFR) to correlate with higher metastasis in NPC patients, and show cLIF to promote NPC metastasis and vascular dissemination via the YAP1-FAK/PXN axis.
format	article
author	Shu-Chen Liu Tien Hsu Yu-Sun Chang An-Ko Chung Shih Sheng Jiang Chun-Nan OuYang Chiou-Hwa Yuh Chuen Hsueh Ya-Ping Liu Ngan-Ming Tsang
author_facet	Shu-Chen Liu Tien Hsu Yu-Sun Chang An-Ko Chung Shih Sheng Jiang Chun-Nan OuYang Chiou-Hwa Yuh Chuen Hsueh Ya-Ping Liu Ngan-Ming Tsang
author_sort	Shu-Chen Liu
title	Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
title_short	Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
title_full	Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
title_fullStr	Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
title_full_unstemmed	Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling
title_sort	cytoplasmic lif reprograms invasive mode to enhance npc dissemination through modulating yap1-fak/pxn signaling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5859dcee62b843f5bc95e474b541df8d
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Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

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