EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.

EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.

Overexpression of ecotropic viral integration site 1 (EVI1) is associated with aggressive disease in acute myeloid leukemia (AML). Despite of its clinical importance, little is known about the mechanism through which EVI1 confers resistance to antileukemic drugs. Here, we show that a human myeloid c...

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Auteurs principaux: Anna Rommer, Birgit Steinmetz, Friederike Herbst, Hubert Hackl, Petra Heffeter, Daniela Heilos, Martin Filipits, Katarina Steinleitner, Shayda Hemmati, Irene Herbacek, Ilse Schwarzinger, Katharina Hartl, Pieter Rondou, Hanno Glimm, Kadin Karakaya, Alwin Krämer, Walter Berger, Rotraud Wieser
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/585c0852f1d94e859d4e2ecfd8b60976
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