Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling mediated trophectoderm morphogenesis orchestrate...

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Autores principales:	Neophytos Christodoulou, Antonia Weberling, Douglas Strathdee, Kurt I. Anderson, Paul Timpson, Magdalena Zernicka-Goetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58a335804b094ccb914b55fdc92e5ec9
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spelling	oai:doaj.org-article:58a335804b094ccb914b55fdc92e5ec92021-12-02T14:35:55ZMorphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation10.1038/s41467-019-11482-52041-1723https://doaj.org/article/58a335804b094ccb914b55fdc92e5ec92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11482-5https://doaj.org/toc/2041-1723How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling mediated trophectoderm morphogenesis orchestrates this process.Neophytos ChristodoulouAntonia WeberlingDouglas StrathdeeKurt I. AndersonPaul TimpsonMagdalena Zernicka-GoetzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neophytos Christodoulou Antonia Weberling Douglas Strathdee Kurt I. Anderson Paul Timpson Magdalena Zernicka-Goetz Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
description	How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling mediated trophectoderm morphogenesis orchestrates this process.
format	article
author	Neophytos Christodoulou Antonia Weberling Douglas Strathdee Kurt I. Anderson Paul Timpson Magdalena Zernicka-Goetz
author_facet	Neophytos Christodoulou Antonia Weberling Douglas Strathdee Kurt I. Anderson Paul Timpson Magdalena Zernicka-Goetz
author_sort	Neophytos Christodoulou
title	Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
title_short	Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
title_full	Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
title_fullStr	Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
title_full_unstemmed	Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
title_sort	morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/58a335804b094ccb914b55fdc92e5ec9
work_keys_str_mv	AT neophytoschristodoulou morphogenesisofextraembryonictissuesdirectstheremodellingofthemouseembryoatimplantation AT antoniaweberling morphogenesisofextraembryonictissuesdirectstheremodellingofthemouseembryoatimplantation AT douglasstrathdee morphogenesisofextraembryonictissuesdirectstheremodellingofthemouseembryoatimplantation AT kurtianderson morphogenesisofextraembryonictissuesdirectstheremodellingofthemouseembryoatimplantation AT paultimpson morphogenesisofextraembryonictissuesdirectstheremodellingofthemouseembryoatimplantation AT magdalenazernickagoetz morphogenesisofextraembryonictissuesdirectstheremodellingofthemouseembryoatimplantation
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Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

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