Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

A better understanding of the relationships between vaccine, immunogenicity and protection from disease would greatly facilitate vaccine development. Modified vaccinia virus Ankara expressing antigen 85A (MVA85A) is a novel tuberculosis vaccine candidate designed to enhance responses induced by BCG....

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Autores principales: Magali Matsumiya, Elena Stylianou, Kristin Griffiths, Zoe Lang, Joel Meyer, Stephanie A Harris, Rosalind Rowland, Angela M Minassian, Ansar A Pathan, Helen Fletcher, Helen McShane
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
Q
Acceso en línea:https://doaj.org/article/58cafdfb650f4af69c100d33f85ac92f
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https://doaj.org/article/58cafdfb650f4af69c100d33f85ac92f

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