Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation

The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.

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Autores principales: Shunsuke Hasegawa, Hotaka Fukushima, Hiroshi Hosoda, Tatsurou Serita, Rie Ishikawa, Tomohiro Rokukawa, Ryouka Kawahara-Miki, Yue Zhang, Miho Ohta, Shintaro Okada, Toshiyuki Tanimizu, Sheena A. Josselyn, Paul W. Frankland, Satoshi Kida
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/58cfaf7133c44f2abb529a34f9248cd2
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spelling oai:doaj.org-article:58cfaf7133c44f2abb529a34f9248cd22021-12-02T14:38:44ZHippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation10.1038/s41467-019-13554-y2041-1723https://doaj.org/article/58cfaf7133c44f2abb529a34f9248cd22019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13554-yhttps://doaj.org/toc/2041-1723The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.Shunsuke HasegawaHotaka FukushimaHiroshi HosodaTatsurou SeritaRie IshikawaTomohiro RokukawaRyouka Kawahara-MikiYue ZhangMiho OhtaShintaro OkadaToshiyuki TanimizuSheena A. JosselynPaul W. FranklandSatoshi KidaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shunsuke Hasegawa
Hotaka Fukushima
Hiroshi Hosoda
Tatsurou Serita
Rie Ishikawa
Tomohiro Rokukawa
Ryouka Kawahara-Miki
Yue Zhang
Miho Ohta
Shintaro Okada
Toshiyuki Tanimizu
Sheena A. Josselyn
Paul W. Frankland
Satoshi Kida
Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
description The neural mechanisms that lead to a relative deficit in memory retrieval in the afternoon are unclear. Here, the authors show that the circadian - dependent transcription factor BMAL1 regulates retrieval through dopamine and glutamate receptor phosphorylation.
format article
author Shunsuke Hasegawa
Hotaka Fukushima
Hiroshi Hosoda
Tatsurou Serita
Rie Ishikawa
Tomohiro Rokukawa
Ryouka Kawahara-Miki
Yue Zhang
Miho Ohta
Shintaro Okada
Toshiyuki Tanimizu
Sheena A. Josselyn
Paul W. Frankland
Satoshi Kida
author_facet Shunsuke Hasegawa
Hotaka Fukushima
Hiroshi Hosoda
Tatsurou Serita
Rie Ishikawa
Tomohiro Rokukawa
Ryouka Kawahara-Miki
Yue Zhang
Miho Ohta
Shintaro Okada
Toshiyuki Tanimizu
Sheena A. Josselyn
Paul W. Frankland
Satoshi Kida
author_sort Shunsuke Hasegawa
title Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
title_short Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
title_full Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
title_fullStr Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
title_full_unstemmed Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
title_sort hippocampal clock regulates memory retrieval via dopamine and pka-induced glua1 phosphorylation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/58cfaf7133c44f2abb529a34f9248cd2
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