Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi protein, through mutation of its specificity loop.

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Autores principales: Chad B. Stein, Pavol Genzor, Sanga Mitra, Alexandra R. Elchert, Jonathan J. Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D. Haase
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/58d34676a5714e7abafef2822ed72676
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https://doaj.org/article/58d34676a5714e7abafef2822ed72676

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