Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi protein, through mutation of its specificity loop.

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Autores principales:	Chad B. Stein, Pavol Genzor, Sanga Mitra, Alexandra R. Elchert, Jonathan J. Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D. Haase
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/58d34676a5714e7abafef2822ed72676
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spelling	oai:doaj.org-article:58d34676a5714e7abafef2822ed726762021-12-02T14:39:57ZDecoding the 5′ nucleotide bias of PIWI-interacting RNAs10.1038/s41467-019-08803-z2041-1723https://doaj.org/article/58d34676a5714e7abafef2822ed726762019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08803-zhttps://doaj.org/toc/2041-1723PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi protein, through mutation of its specificity loop.Chad B. SteinPavol GenzorSanga MitraAlexandra R. ElchertJonathan J. IpsaroLeif BennerSushil SobtiYijun SuMolly HammellLeemor Joshua-TorAstrid D. HaaseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chad B. Stein Pavol Genzor Sanga Mitra Alexandra R. Elchert Jonathan J. Ipsaro Leif Benner Sushil Sobti Yijun Su Molly Hammell Leemor Joshua-Tor Astrid D. Haase Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
description	PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi protein, through mutation of its specificity loop.
format	article
author	Chad B. Stein Pavol Genzor Sanga Mitra Alexandra R. Elchert Jonathan J. Ipsaro Leif Benner Sushil Sobti Yijun Su Molly Hammell Leemor Joshua-Tor Astrid D. Haase
author_facet	Chad B. Stein Pavol Genzor Sanga Mitra Alexandra R. Elchert Jonathan J. Ipsaro Leif Benner Sushil Sobti Yijun Su Molly Hammell Leemor Joshua-Tor Astrid D. Haase
author_sort	Chad B. Stein
title	Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
title_short	Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
title_full	Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
title_fullStr	Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
title_full_unstemmed	Decoding the 5′ nucleotide bias of PIWI-interacting RNAs
title_sort	decoding the 5′ nucleotide bias of piwi-interacting rnas
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/58d34676a5714e7abafef2822ed72676
work_keys_str_mv	AT chadbstein decodingthe5nucleotidebiasofpiwiinteractingrnas AT pavolgenzor decodingthe5nucleotidebiasofpiwiinteractingrnas AT sangamitra decodingthe5nucleotidebiasofpiwiinteractingrnas AT alexandrarelchert decodingthe5nucleotidebiasofpiwiinteractingrnas AT jonathanjipsaro decodingthe5nucleotidebiasofpiwiinteractingrnas AT leifbenner decodingthe5nucleotidebiasofpiwiinteractingrnas AT sushilsobti decodingthe5nucleotidebiasofpiwiinteractingrnas AT yijunsu decodingthe5nucleotidebiasofpiwiinteractingrnas AT mollyhammell decodingthe5nucleotidebiasofpiwiinteractingrnas AT leemorjoshuator decodingthe5nucleotidebiasofpiwiinteractingrnas AT astriddhaase decodingthe5nucleotidebiasofpiwiinteractingrnas
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Decoding the 5′ nucleotide bias of PIWI-interacting RNAs

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