A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

Ataxia Telangiectasia (A-T) and Ataxia with Ocular Apraxia Type 1 (AOA1) are devastating neurological disorders caused by null mutations in the genome stability genes, A-T mutated (ATM) and Aprataxin (APTX), respectively. Our mechanistic understanding and therapeutic repertoire for treating these di...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Harvey Perez, May F Abdallah, Jose I Chavira, Angelina S Norris, Martin T Egeland, Karen L Vo, Callan L Buechsenschuetz, Valentina Sanghez, Jeannie L Kim, Molly Pind, Kotoka Nakamura, Geoffrey G Hicks, Richard A Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J McKinnon, Paul J Mathews
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
Ataxia Telangiectasia
cerebellum
purkinje neurons
ataxia
thymus
cancer
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/58f72a12e1074e83ad3fff4ba229dc94
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/58f72a12e1074e83ad3fff4ba229dc94

Ejemplares similares