Novel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina

Abstract Despite efficient and specific in vitro knockdown, more reliable and convenient methods for in vivo knockdown of target genes remain to be developed particularly for retinal research. Using commercially available and chemically modified siRNA so-called Accell siRNA, we established a novel i...

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Autores principales: Takazumi Taniguchi, Ken-ichi Endo, Hidetoshi Tanioka, Masaaki Sasaoka, Kei Tashiro, Shigeru Kinoshita, Masaaki Kageyama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/592188d10cff4b4fb91119369b563593
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