Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strain...

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Autores principales:	Mark A. T. Blaskovich, Karl A. Hansford, Yujing Gong, Mark S. Butler, Craig Muldoon, Johnny X. Huang, Soumya Ramu, Alberto B. Silva, Mu Cheng, Angela M. Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A. Bradford, June C. Lee, Tomislav Karoli, Ruby Pelingon, David J. Edwards, Maite Amado, Alysha G. Elliott, Wanida Phetsang, Noor Huda Daud, Johan E. Deecke, Hanna E. Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R. Betley, Andrew P. G. Beevers, Richard A. G. Smith, Jason A. Roberts, David L. Paterson, Matthew A. Cooper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c490
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spelling	oai:doaj.org-article:5939bc54d4b347d7b1b16946d6d5c4902021-12-02T14:39:24ZProtein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria10.1038/s41467-017-02123-w2041-1723https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c4902018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02123-whttps://doaj.org/toc/2041-1723The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strains.Mark A. T. BlaskovichKarl A. HansfordYujing GongMark S. ButlerCraig MuldoonJohnny X. HuangSoumya RamuAlberto B. SilvaMu ChengAngela M. KavanaghZyta ZioraRajaratnam PremrajFredrik LindahlTanya A. BradfordJune C. LeeTomislav KaroliRuby PelingonDavid J. EdwardsMaite AmadoAlysha G. ElliottWanida PhetsangNoor Huda DaudJohan E. DeeckeHanna E. SidjabatSefetogi RamaologaJohannes ZueggJason R. BetleyAndrew P. G. BeeversRichard A. G. SmithJason A. RobertsDavid L. PatersonMatthew A. CooperNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mark A. T. Blaskovich Karl A. Hansford Yujing Gong Mark S. Butler Craig Muldoon Johnny X. Huang Soumya Ramu Alberto B. Silva Mu Cheng Angela M. Kavanagh Zyta Ziora Rajaratnam Premraj Fredrik Lindahl Tanya A. Bradford June C. Lee Tomislav Karoli Ruby Pelingon David J. Edwards Maite Amado Alysha G. Elliott Wanida Phetsang Noor Huda Daud Johan E. Deecke Hanna E. Sidjabat Sefetogi Ramaologa Johannes Zuegg Jason R. Betley Andrew P. G. Beevers Richard A. G. Smith Jason A. Roberts David L. Paterson Matthew A. Cooper Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
description	The antibiotic vancomycin inhibits bacterial cell wall synthesis by binding to a membrane-associated precursor. Here, Blaskovich et al. synthesize vancomycin derivatives containing lipophilic peptide moieties that enhance membrane affinity and in vivo activities against glycopeptide-resistant strains.
format	article
author	Mark A. T. Blaskovich Karl A. Hansford Yujing Gong Mark S. Butler Craig Muldoon Johnny X. Huang Soumya Ramu Alberto B. Silva Mu Cheng Angela M. Kavanagh Zyta Ziora Rajaratnam Premraj Fredrik Lindahl Tanya A. Bradford June C. Lee Tomislav Karoli Ruby Pelingon David J. Edwards Maite Amado Alysha G. Elliott Wanida Phetsang Noor Huda Daud Johan E. Deecke Hanna E. Sidjabat Sefetogi Ramaologa Johannes Zuegg Jason R. Betley Andrew P. G. Beevers Richard A. G. Smith Jason A. Roberts David L. Paterson Matthew A. Cooper
author_facet	Mark A. T. Blaskovich Karl A. Hansford Yujing Gong Mark S. Butler Craig Muldoon Johnny X. Huang Soumya Ramu Alberto B. Silva Mu Cheng Angela M. Kavanagh Zyta Ziora Rajaratnam Premraj Fredrik Lindahl Tanya A. Bradford June C. Lee Tomislav Karoli Ruby Pelingon David J. Edwards Maite Amado Alysha G. Elliott Wanida Phetsang Noor Huda Daud Johan E. Deecke Hanna E. Sidjabat Sefetogi Ramaologa Johannes Zuegg Jason R. Betley Andrew P. G. Beevers Richard A. G. Smith Jason A. Roberts David L. Paterson Matthew A. Cooper
author_sort	Mark A. T. Blaskovich
title	Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
title_short	Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
title_full	Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
title_fullStr	Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
title_full_unstemmed	Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
title_sort	protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5939bc54d4b347d7b1b16946d6d5c490
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Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

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