IL-10 Signaling Elicited by Nivolumab-Induced Activation of the MAP Kinase Pathway Does Not Fully Contribute to Nivolumab-Modulated Heterogeneous T Cell Responses

IL-10 Signaling Elicited by Nivolumab-Induced Activation of the MAP Kinase Pathway Does Not Fully Contribute to Nivolumab-Modulated Heterogeneous T Cell Responses

Immune checkpoint inhibitor (ICI) therapy has revolutionized anti-cancer treatment for many late-stage cancer patients. However, ICI therapy has thus far demonstrated limited efficacy for most patients, and it remains unclear why this is so. Interleukin 10 (IL-10) is a cytokine that has been recogni...

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Bibliographic Details
Main Authors: Taylor A. Harper, Silvia M. Bacot, Christie Jane Fennell, Rebecca L. Matthews, Christina Zhu, Peng Yue, Alexander Benton, Devira Friedman, Adovi Akue, Mark A. KuKuruga, Shiowjen Lee, Tao Wang, Gerald M. Feldman
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
nivolumab
interleukin 10
T cells
cytokines
STAT3 pathway
AKT serine–threonine kinase pathway
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/593e5988af814e43a4f69208f2a1b7c8
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