Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

ABSTRACT The clinical severity and annual occurrence of influenza virus epidemics, combined with the availability of just a single class of antivirals to treat infections, underscores the urgent need to develop new anti-influenza drugs. The endonuclease activity within the viral acidic polymerase (P...

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Autores principales: Jeremy C. Jones, Gyanendra Kumar, Subrata Barman, Isabel Najera, Stephen W. White, Richard J. Webby, Elena A. Govorkova
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
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Acceso en línea:https://doaj.org/article/5940f8b8414e4365ae732284ea1aaabd
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