Discovery of a siderophore export system essential for virulence of Mycobacterium tuberculosis.

Iron is an essential nutrient for most bacterial pathogens, but is restricted by the host immune system. Mycobacterium tuberculosis (Mtb) utilizes two classes of small molecules, mycobactins and carboxymycobactins, to capture iron from the human host. Here, we show that an Mtb mutant lacking the mmp...

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Autores principales: Ryan M Wells, Christopher M Jones, Zhaoyong Xi, Alexander Speer, Olga Danilchanka, Kathryn S Doornbos, Peibei Sun, Fangming Wu, Changlin Tian, Michael Niederweis
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/594c56aa3fef4488ad8a61059f35372d
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