Transcriptome analysis and prognosis of ALDH isoforms in human cancer

Abstract Overexpression of ALDH is associated with cancer stem-like features and poor cancer prognosis. High ALDH activity has been observed in cancer stem-like cells. There are a total of 19 human ALDH isoforms, all of which are associated with reducing oxidative stress and protecting cells from da...

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Autores principales:	Peter Mu-Hsin Chang, Che-Hong Chen, Chi-Chun Yeh, Hsueh-Ju Lu, Tze-Tze Liu, Ming-Huang Chen, Chun-Yu Liu, Alexander T. H. Wu, Muh-Hwa Yang, Shyh-Kuan Tai, Daria Mochly-Rosen, Chi-Ying F. Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59891f00cc43432ba9a73759762ec0b6
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spelling	oai:doaj.org-article:59891f00cc43432ba9a73759762ec0b62021-12-02T15:08:15ZTranscriptome analysis and prognosis of ALDH isoforms in human cancer10.1038/s41598-018-21123-42045-2322https://doaj.org/article/59891f00cc43432ba9a73759762ec0b62018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21123-4https://doaj.org/toc/2045-2322Abstract Overexpression of ALDH is associated with cancer stem-like features and poor cancer prognosis. High ALDH activity has been observed in cancer stem-like cells. There are a total of 19 human ALDH isoforms, all of which are associated with reducing oxidative stress and protecting cells from damage. However, it is unknown whether all ALDHs are associated with poor cancer prognosis and which ones play a significant role in cancer progression. In this study, we used RNA sequencing data from The Cancer Genome Atlas (TCGA) to evaluate the differential expression of 19 ALDH isoforms in 5 common human cancers. The 19 ALDH genes were analyzed with an integrating meta-analysis of cancer prognosis. Genotyping and next-generation RNA sequencing for 30 pairwise samples of head and neck squamous cell carcinoma were performed and compared with the TCGA cohort. The analysis showed that each ALDH isoform had a specific differential expression pattern, most of which were related to prognosis in human cancer. A lower expression of ALDH2 in the tumor was observed, which was independent from the ALDH2 rs671 SNP variant and the expression of other mitochondria-associated protein coding genes. This study provides new insight into the association between ALDH expression and cancer prognosis.Peter Mu-Hsin ChangChe-Hong ChenChi-Chun YehHsueh-Ju LuTze-Tze LiuMing-Huang ChenChun-Yu LiuAlexander T. H. WuMuh-Hwa YangShyh-Kuan TaiDaria Mochly-RosenChi-Ying F. HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Mu-Hsin Chang Che-Hong Chen Chi-Chun Yeh Hsueh-Ju Lu Tze-Tze Liu Ming-Huang Chen Chun-Yu Liu Alexander T. H. Wu Muh-Hwa Yang Shyh-Kuan Tai Daria Mochly-Rosen Chi-Ying F. Huang Transcriptome analysis and prognosis of ALDH isoforms in human cancer
description	Abstract Overexpression of ALDH is associated with cancer stem-like features and poor cancer prognosis. High ALDH activity has been observed in cancer stem-like cells. There are a total of 19 human ALDH isoforms, all of which are associated with reducing oxidative stress and protecting cells from damage. However, it is unknown whether all ALDHs are associated with poor cancer prognosis and which ones play a significant role in cancer progression. In this study, we used RNA sequencing data from The Cancer Genome Atlas (TCGA) to evaluate the differential expression of 19 ALDH isoforms in 5 common human cancers. The 19 ALDH genes were analyzed with an integrating meta-analysis of cancer prognosis. Genotyping and next-generation RNA sequencing for 30 pairwise samples of head and neck squamous cell carcinoma were performed and compared with the TCGA cohort. The analysis showed that each ALDH isoform had a specific differential expression pattern, most of which were related to prognosis in human cancer. A lower expression of ALDH2 in the tumor was observed, which was independent from the ALDH2 rs671 SNP variant and the expression of other mitochondria-associated protein coding genes. This study provides new insight into the association between ALDH expression and cancer prognosis.
format	article
author	Peter Mu-Hsin Chang Che-Hong Chen Chi-Chun Yeh Hsueh-Ju Lu Tze-Tze Liu Ming-Huang Chen Chun-Yu Liu Alexander T. H. Wu Muh-Hwa Yang Shyh-Kuan Tai Daria Mochly-Rosen Chi-Ying F. Huang
author_facet	Peter Mu-Hsin Chang Che-Hong Chen Chi-Chun Yeh Hsueh-Ju Lu Tze-Tze Liu Ming-Huang Chen Chun-Yu Liu Alexander T. H. Wu Muh-Hwa Yang Shyh-Kuan Tai Daria Mochly-Rosen Chi-Ying F. Huang
author_sort	Peter Mu-Hsin Chang
title	Transcriptome analysis and prognosis of ALDH isoforms in human cancer
title_short	Transcriptome analysis and prognosis of ALDH isoforms in human cancer
title_full	Transcriptome analysis and prognosis of ALDH isoforms in human cancer
title_fullStr	Transcriptome analysis and prognosis of ALDH isoforms in human cancer
title_full_unstemmed	Transcriptome analysis and prognosis of ALDH isoforms in human cancer
title_sort	transcriptome analysis and prognosis of aldh isoforms in human cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/59891f00cc43432ba9a73759762ec0b6
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_version_	1718388186226360320

Transcriptome analysis and prognosis of ALDH isoforms in human cancer

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