Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.

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Auteurs principaux: Xiaolu Ma, Hongmei Liu, Jing Li, Yihao Wang, Yue-He Ding, Hongyan Shen, Yeran Yang, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, Meng-Qiu Dong, Ping Xu, Tie-Shan Tang, Caixia Guo
Format: article
Langue:EN
Publié: Nature Portfolio 2017
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/599494d1f24f4a00a4388d28f4e28b0b
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https://doaj.org/article/599494d1f24f4a00a4388d28f4e28b0b

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