Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.

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Autores principales: Xiaolu Ma, Hongmei Liu, Jing Li, Yihao Wang, Yue-He Ding, Hongyan Shen, Yeran Yang, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, Meng-Qiu Dong, Ping Xu, Tie-Shan Tang, Caixia Guo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/599494d1f24f4a00a4388d28f4e28b0b
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spelling oai:doaj.org-article:599494d1f24f4a00a4388d28f4e28b0b2021-12-02T14:42:17ZPolη O-GlcNAcylation governs genome integrity during translesion DNA synthesis10.1038/s41467-017-02164-12041-1723https://doaj.org/article/599494d1f24f4a00a4388d28f4e28b0b2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02164-1https://doaj.org/toc/2041-1723Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.Xiaolu MaHongmei LiuJing LiYihao WangYue-He DingHongyan ShenYeran YangChenyi SunMin HuangYingfeng TuYang LiuYongliang ZhaoMeng-Qiu DongPing XuTie-Shan TangCaixia GuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaolu Ma
Hongmei Liu
Jing Li
Yihao Wang
Yue-He Ding
Hongyan Shen
Yeran Yang
Chenyi Sun
Min Huang
Yingfeng Tu
Yang Liu
Yongliang Zhao
Meng-Qiu Dong
Ping Xu
Tie-Shan Tang
Caixia Guo
Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
description Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.
format article
author Xiaolu Ma
Hongmei Liu
Jing Li
Yihao Wang
Yue-He Ding
Hongyan Shen
Yeran Yang
Chenyi Sun
Min Huang
Yingfeng Tu
Yang Liu
Yongliang Zhao
Meng-Qiu Dong
Ping Xu
Tie-Shan Tang
Caixia Guo
author_facet Xiaolu Ma
Hongmei Liu
Jing Li
Yihao Wang
Yue-He Ding
Hongyan Shen
Yeran Yang
Chenyi Sun
Min Huang
Yingfeng Tu
Yang Liu
Yongliang Zhao
Meng-Qiu Dong
Ping Xu
Tie-Shan Tang
Caixia Guo
author_sort Xiaolu Ma
title Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_short Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_full Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_fullStr Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_full_unstemmed Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_sort polη o-glcnacylation governs genome integrity during translesion dna synthesis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/599494d1f24f4a00a4388d28f4e28b0b
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