Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.

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Autores principales:	Xiaojing Chi, Xiuying Liu, Conghui Wang, Xinhui Zhang, Xiang Li, Jianhua Hou, Lili Ren, Qi Jin, Jianwei Wang, Wei Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5a2adb117bc54fe7a3edefdf76d0df98
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spelling	oai:doaj.org-article:5a2adb117bc54fe7a3edefdf76d0df982021-12-02T17:19:41ZHumanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain10.1038/s41467-020-18387-82041-1723https://doaj.org/article/5a2adb117bc54fe7a3edefdf76d0df982020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18387-8https://doaj.org/toc/2041-1723Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.Xiaojing ChiXiuying LiuConghui WangXinhui ZhangXiang LiJianhua HouLili RenQi JinJianwei WangWei YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaojing Chi Xiuying Liu Conghui Wang Xinhui Zhang Xiang Li Jianhua Hou Lili Ren Qi Jin Jianwei Wang Wei Yang Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
description	Here, using a humanized phage display library with recombinant SARS- CoV-2 receptor binding domain (RBD) proteins, the authors identify a number of single domain antibodies (sdAbs) that neutralize SARS-CoV-2 in vitro by inhibiting the interaction of the RDB with the host entry receptor ACE2.
format	article
author	Xiaojing Chi Xiuying Liu Conghui Wang Xinhui Zhang Xiang Li Jianhua Hou Lili Ren Qi Jin Jianwei Wang Wei Yang
author_facet	Xiaojing Chi Xiuying Liu Conghui Wang Xinhui Zhang Xiang Li Jianhua Hou Lili Ren Qi Jin Jianwei Wang Wei Yang
author_sort	Xiaojing Chi
title	Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
title_short	Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
title_full	Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
title_fullStr	Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
title_full_unstemmed	Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
title_sort	humanized single domain antibodies neutralize sars-cov-2 by targeting the spike receptor binding domain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5a2adb117bc54fe7a3edefdf76d0df98
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Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

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