De novo [PSI +] prion formation involves multiple pathways to form infectious oligomers

Abstract Prion and other neurodegenerative diseases are associated with misfolded protein assemblies called amyloid. Research has begun to uncover common mechanisms underlying transmission of amyloids, yet how amyloids form in vivo is still unclear. Here, we take advantage of the yeast prion, [PSI +...

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Autores principales: Jaya Sharma, Brett T. Wisniewski, Emily Paulson, Joanna O. Obaoye, Stephen J. Merrill, Anita L. Manogaran
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5a38227647ac4f6fa2ac72c486fdc23c
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