RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines

Abstract Ras-specific proteases to degrade RAS within cancer cells are under active development as an innovative strategy to treat tumorigenesis. The naturally occurring biological toxin effector called RAS/RAP1-specific endopeptidase (RRSP) is known to cleave all RAS within a cell, including HRAS,...

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Autores principales: Caleb K. Stubbs, Marco Biancucci, Vania Vidimar, Karla J. F. Satchell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5a5574419aae44be93fd81d61bb47664
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