RAS specific protease induces irreversible growth arrest via p27 in several KRAS mutant colorectal cancer cell lines
Abstract Ras-specific proteases to degrade RAS within cancer cells are under active development as an innovative strategy to treat tumorigenesis. The naturally occurring biological toxin effector called RAS/RAP1-specific endopeptidase (RRSP) is known to cleave all RAS within a cell, including HRAS,...
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Autores principales: | Caleb K. Stubbs, Marco Biancucci, Vania Vidimar, Karla J. F. Satchell |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/5a5574419aae44be93fd81d61bb47664 |
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