T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the...

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Autores principales: Aakanksha Jain, Ran Song, Edward K. Wakeland, Chandrashekhar Pasare
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5a633d6c97f64ce594f648e00b0e6574
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