T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the...

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Autores principales: Aakanksha Jain, Ran Song, Edward K. Wakeland, Chandrashekhar Pasare
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5a633d6c97f64ce594f648e00b0e6574
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spelling oai:doaj.org-article:5a633d6c97f64ce594f648e00b0e65742021-12-02T16:56:59ZT cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells10.1038/s41467-018-05489-72041-1723https://doaj.org/article/5a633d6c97f64ce594f648e00b0e65742018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05489-7https://doaj.org/toc/2041-1723CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.Aakanksha JainRan SongEdward K. WakelandChandrashekhar PasareNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aakanksha Jain
Ran Song
Edward K. Wakeland
Chandrashekhar Pasare
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
description CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.
format article
author Aakanksha Jain
Ran Song
Edward K. Wakeland
Chandrashekhar Pasare
author_facet Aakanksha Jain
Ran Song
Edward K. Wakeland
Chandrashekhar Pasare
author_sort Aakanksha Jain
title T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_short T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_full T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_fullStr T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_full_unstemmed T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_sort t cell-intrinsic il-1r signaling licenses effector cytokine production by memory cd4 t cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5a633d6c97f64ce594f648e00b0e6574
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