T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the...

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Auteurs principaux:	Aakanksha Jain, Ran Song, Edward K. Wakeland, Chandrashekhar Pasare
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/5a633d6c97f64ce594f648e00b0e6574
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id	oai:doaj.org-article:5a633d6c97f64ce594f648e00b0e6574
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spelling	oai:doaj.org-article:5a633d6c97f64ce594f648e00b0e65742021-12-02T16:56:59ZT cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells10.1038/s41467-018-05489-72041-1723https://doaj.org/article/5a633d6c97f64ce594f648e00b0e65742018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05489-7https://doaj.org/toc/2041-1723CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.Aakanksha JainRan SongEdward K. WakelandChandrashekhar PasareNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
description	CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.
format	article
author	Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare
author_facet	Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare
author_sort	Aakanksha Jain
title	T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_short	T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_full	T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_fullStr	T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_full_unstemmed	T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
title_sort	t cell-intrinsic il-1r signaling licenses effector cytokine production by memory cd4 t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5a633d6c97f64ce594f648e00b0e6574
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_version_	1718382681594527744

T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells

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