T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells
CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the...
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Nature Portfolio
2018
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oai:doaj.org-article:5a633d6c97f64ce594f648e00b0e65742021-12-02T16:56:59ZT cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells10.1038/s41467-018-05489-72041-1723https://doaj.org/article/5a633d6c97f64ce594f648e00b0e65742018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05489-7https://doaj.org/toc/2041-1723CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets.Aakanksha JainRan SongEdward K. WakelandChandrashekhar PasareNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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Science Q Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
description |
CD4 T cell polarizations and functions are regulated by cytokines from innate cells. Here the authors show that IL-1 deficiency does not impair the differentiation of Th1, Th2 and Th17, but IL-1 signaling is required for maintaining the expressions of their respective key cytokines to ‘license’ the functions of these T cell subsets. |
format |
article |
author |
Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare |
author_facet |
Aakanksha Jain Ran Song Edward K. Wakeland Chandrashekhar Pasare |
author_sort |
Aakanksha Jain |
title |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_short |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_full |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_fullStr |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_full_unstemmed |
T cell-intrinsic IL-1R signaling licenses effector cytokine production by memory CD4 T cells |
title_sort |
t cell-intrinsic il-1r signaling licenses effector cytokine production by memory cd4 t cells |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/5a633d6c97f64ce594f648e00b0e6574 |
work_keys_str_mv |
AT aakankshajain tcellintrinsicil1rsignalinglicenseseffectorcytokineproductionbymemorycd4tcells AT ransong tcellintrinsicil1rsignalinglicenseseffectorcytokineproductionbymemorycd4tcells AT edwardkwakeland tcellintrinsicil1rsignalinglicenseseffectorcytokineproductionbymemorycd4tcells AT chandrashekharpasare tcellintrinsicil1rsignalinglicenseseffectorcytokineproductionbymemorycd4tcells |
_version_ |
1718382681594527744 |