Model Identifies Genetic Predisposition of Alzheimer’s Disease as Key Decider in Cell Susceptibility to Stress

Accumulation of unfolded/misfolded proteins in neuronal cells perturbs endoplasmic reticulum homeostasis, triggering a stress cascade called unfolded protein response (UPR), markers of which are upregulated in Alzheimer’s disease (AD) brain specimens. We measured the UPR dynamic response in three hu...

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Bibliographic Details
Main Authors: Ioanna C. Stefani, François-Xavier Blaudin de Thé, Cleo Kontoravdi, Karen M. Polizzi
Format: article
Language:EN
Published: MDPI AG 2021
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Online Access:https://doaj.org/article/5a6cba5835624cd4a206738c6ed43383
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